How far back can an eeg detect a seizure trial#
01).Ĭonclusions and Relevance This pragmatic trial shows that in critically ill adults with impaired consciousness and no recent seizure, cEEG leads to increased seizure detection and modification of antiseizure treatment but is not related to improved outcome compared with repeated rEEG. 001, respectively) and more frequent adaptations in antiseizure therapy (RR, 1.84 95% CI, 1.12-3.00 P =. Continuous EEG was associated with increased detection of interictal features and seizures (adjusted RR, 1.26 95% CI, 1.08-1.15 P =. Exploratory comparisons within subgroups stratifying patients according to age, premorbid disability, comorbidities on admission, deeper consciousness reduction, and underlying diagnoses revealed no significant effect modification. At 6 months, mortality was 89 of 182 in those with cEEG and 88 of 182 in those with rEEG (adjusted relative risk, 1.02 95% CI, 0.83-1.26 P =. Results We analyzed 364 patients (33% women mean age, 63 years). Secondary outcomes included interictal and ictal features detection and change in therapy. Main Outcomes and Measures Mortality at 6 months represented the primary outcome. Interventions Participants were randomized 1:1 to cEEG for 30 to 48 hours vs 2 rEEGs (20 minutes each), interpreted according to standardized American Clinical Neurophysiology Society guidelines. An independent physician provided emergency informed consent. They had cerebral (eg, brain trauma, cardiac arrest, hemorrhage, or stroke) or noncerebral conditions (eg, toxic-metabolic or unknown etiology), and EEG was requested as part of standard care.
How far back can an eeg detect a seizure full#
Depending on investigators’ availability, we pragmatically recruited critically ill adults having Glasgow Coma Scale scores of 11 or less or Full Outline of Responsiveness score of 12 or less, without recent seizures or status epilepticus. Outcomes were assessed by interviewers blinded to interventions.The study took place at 4 tertiary hospitals in Switzerland (intensive and intermediate care units).
Objective To assess whether cEEG is associated with reduced mortality compared with rEEG.ĭesign, Setting, and Participants The pragmatic multicenter Continuous EEG Randomized Trial in Adults (CERTA) was conducted between 20, with follow-up of 6 months. It is also uncertain whether cEEG has an effect on outcome.
Importance In critically ill patients with altered consciousness, continuous electroencephalogram (cEEG) improves seizure detection, but is resource-consuming compared with routine EEG (rEEG). Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.
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